How It Works

How PRESERVE™ works

Below is the short version of why creatine monohydrate is the supplement most pharmacists and clinical researchers now recommend to adults 50+ on a GLP-1 medication — and how PRESERVE™ delivers it in a form that fits real life.

Step 1 — Your GLP-1 cuts your appetite, by design

GLP-1 receptor agonists (Ozempic®, Wegovy®, Mounjaro®, Zepbound®) reduce hunger signaling, slow gastric emptying, and effectively lower your caloric intake by 40-60% in most patients. That's the mechanism. That's the weight loss.

Step 2 — Lower caloric intake = some muscle loss

Whenever your body is in caloric deficit, it pulls fuel from both fat tissue AND muscle tissue. The proportion depends on age, baseline muscle mass, protein intake, and activity level. For adults 50+, up to 40% of weight lost can come from lean mass (Endocrine Society 2025; multiple semaglutide and tirzepatide body-composition analyses).

Step 3 — Creatine restores cellular energy

Creatine monohydrate replenishes phosphocreatine stores in your muscle cells. Phosphocreatine is the molecule your cells use to rapidly regenerate ATP — the energy currency of every cellular function, from contracting a muscle to firing a neuron.

When caloric intake drops 40-60%, phosphocreatine drops with it. Your cells become energy-constrained. That's the 2pm crash. That's the brain fog. Creatine fills the gap.

Step 4 — Combined with protein, creatine supports muscle synthesis

Creatine paired with adequate dietary protein activates the mTOR pathway — the cellular signal that tells your body to rebuild muscle. GLP-1 medications appear to slightly dampen this signal. Creatine pushes back. The result: substantially more preserved lean mass over a 12-week protocol than diet alone.*

Step 5 — Why 5 grams. Why gummies. Why 3 a day.

The clinically established dose for muscle preservation is 5g of creatine monohydrate daily. Studies have tested up to 20g with no additional benefit at this dose. Our 3-gummy serving delivers exactly 5g.

Why gummies? The realistic answer: most adults 50+ on GLP-1 medications don't enjoy mixing powder into a chalky shake every morning. Compliance is what determines outcomes. A gummy is the simplest possible delivery form — eat 3 with your morning coffee, the entire daily protocol is done in 8 seconds.

The full 12-week timeline

• Weeks 1-2: saturation phase. Most people feel nothing. That's expected. Creatine works by gradually saturating muscle cells over 21-28 days.
• Weeks 3-4: the first shift. The 2pm crash gets shorter. Brain fog lifts. Energy stabilizes.
• Weeks 5-8: measurable strength. Grip strength improves. Stair-climbing eases. Recovery shortens.
• Weeks 9-12: muscle preservation. The body-composition effect becomes meaningful. If you're doing a DEXA scan, this is when results show up clearly.

After 12 weeks: maintenance. Keep taking 3 gummies daily. Effects compound for as long as you stay consistent.

*Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. PRESERVE™ does not contain GLP-1 or any GLP-1 receptor agonist. Always consult your healthcare provider before starting a new supplement, especially if you take prescription medication.